Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin.

@article{Arenas2010RoleOA,
  title={Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin.},
  author={Iv{\'a}n Arenas and Alejandra Bravo and Mario Sober{\'o}n and Isabel C G{\'o}mez},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 17},
  pages={12497-503}
}
Cry toxins produced by Bacillus thuringiensis have been recognized as pore-forming toxins whose primary action is to lyse midgut epithelial cells in their target insect. In the case of the Cry1A toxins, a prepore oligomeric intermediate is formed after interaction with cadherin receptor. The Cry1A oligomer then interacts with glycosylphosphatidylinositol-anchored receptors. Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP… CONTINUE READING

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