Role of aldosterone in the pathogenesis of hypertension.

  title={Role of aldosterone in the pathogenesis of hypertension.},
  author={P. O. Lim},
  volume={39 2},
  • P. O. Lim
  • Published 2002
  • Biology, Medicine
  • Hypertension
To the Editor: In Rankinen and colleagues’ report,1 the strongest genetic linkage in the whole study was found in chromosome 8q21 (Lod 2.36, P =0.0005) for the effect of exercise training on submaximal exercise systolic blood pressure (BP) response during cycle ergometry at 50 watts. This locus incidentally contains the gene for CYP11B2 that codes for aldosterone synthase, a key rate-limiting enzyme for the biosynthesis of aldosterone. This is an important finding, albeit limited to the… Expand
P-619: Influence of the CYP11B2 -344C/T polymorphism on plasma aldosterone, sodium excretion and blood pressure responses to aerobic exercise training in middle-aged to older prehypertensives
The CYP11B2 -344C/T gene appears to influence the responses of hypertensive phenotypes to AEX in middle-aged to older prehypertensives and BP and PA levels appear to be more responsive to Aex in Caucasians compared to AD. Expand
Association of Adrenal Steroids With Hypertension and the Metabolic Syndrome in Blacks
The association of a Aldosterone with blood pressure, waist circumference, and insulin resistance suggests that aldosterone may contribute to obesity-related hypertension in blacks and it is speculated that relatively high ald testosterone and low PRA in these hypertensive individuals may reflect a mild variant of primary aldosteronism. Expand
Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: A comparison with SHR
In the present study we hypothesized that age-associated changes in the renal aldosterone/mineralocorticoid receptor (MR) system may differ between normotensive Wistar-Kyoto (WKY) and spontaneouslyExpand


Variation at the aldosterone synthase (CYP11B2) locus contributes to hypertension in subjects with a raised aldosterone-to-renin ratio.
The notion that there is a genetic component that regulates aldosterone production and that hyperaldosteronism might develop over time in susceptible individuals is supported. Expand
Essential Hypertension and Aldosterone
The aldosterone content of adrenal glands obtained post mortem from two patients with malignant hypertension was within the range observed by other investigators in primary aldosteronism. Expand
Aldosterone to renin ratio as a determinant of exercise blood pressure response in hypertensive patients
There was an independent and significant correlation between ARR and exercise systolic BP and this index was normalised by natural logarithm (lnARR) for further analyses. Expand
Step test in hypertension.
The physiological basis of essential hypertension is a continuing rise in the systemic vascular resistance (SVR) over time, a process which does not appear to be halted by drug treatment thatExpand
High prevalence of primary aldosteronism in the Tayside hypertension clinic population
The prevalence of primary aldosteronism in Tayside is as high as that in the Australian hypertensive population, and this is likely to be true elsewhere, with obvious important implications for hypertension management. Expand
Effects of physical endurance training on the plasma renin-angiotensin-aldosterone system in normal man.
It is concluded that physical endurance training, leading to a substantial gain of physical working capacity, suppresses the plasma renin-angiotensin-aldosterone system in normal man. Expand
Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements.
Deletion, mutation, and deoxyribonuclease I footprinting analyses of the CYP11B2 5'-flanking region identified two distinct elements at positions -71/-64 (TGACGTGA) and -129/-114 (CTCCAGCCTTGACCTT) that were both required for full basal reporter gene activity and for maximal induction by either cAMP or calcium-signaling pathways. Expand
Genomic Scan for Exercise Blood Pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
A genome-wide linkage scan was performed for genes affecting submaximal exercise systolic blood pressure and diastolicBlood pressure in the sedentary state and their responses to a standardized endurance training program to warrant further studies in the Health, Risk Factors, Exercise Training and Genetics cohort and other studies. Expand
A simple exercise test in borderline and sustained essential hypertension.
Exercise testing can help one diagnose borderline and sustained hypertension and predict the evolution of borderline hypertension toward fixed hypertension. Expand
Hemodynamic changes in the bulbar conjunctival capillary bed of subjects with hypertension associated with Cushing's syndrome or pheochromocytoma.
  • R. E. Lee
  • Medicine
  • The American journal of medicine
  • 1955
No single observed peripheral vascular phenomenon can be described as “characteristic” of hypertensive vascular disease, and it is only when all features observed in the hypertensive capillary bed were considered together that their unique association in this condition becomes apparent. Expand