Role of aldosterone in the pathogenesis of hypertension.

@article{Lim2002RoleOA,
  title={Role of aldosterone in the pathogenesis of hypertension.},
  author={P. O. Lim},
  journal={Hypertension},
  year={2002},
  volume={39 2},
  pages={
          E14
        }
}
  • P. O. Lim
  • Published 2002
  • Biology, Medicine
  • Hypertension
To the Editor: In Rankinen and colleagues’ report,1 the strongest genetic linkage in the whole study was found in chromosome 8q21 (Lod 2.36, P =0.0005) for the effect of exercise training on submaximal exercise systolic blood pressure (BP) response during cycle ergometry at 50 watts. This locus incidentally contains the gene for CYP11B2 that codes for aldosterone synthase, a key rate-limiting enzyme for the biosynthesis of aldosterone. This is an important finding, albeit limited to the… Expand
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The CYP11B2 -344C/T gene appears to influence the responses of hypertensive phenotypes to AEX in middle-aged to older prehypertensives and BP and PA levels appear to be more responsive to Aex in Caucasians compared to AD. Expand
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TLDR
The association of a Aldosterone with blood pressure, waist circumference, and insulin resistance suggests that aldosterone may contribute to obesity-related hypertension in blacks and it is speculated that relatively high ald testosterone and low PRA in these hypertensive individuals may reflect a mild variant of primary aldosteronism. Expand
Long-term food restriction attenuates age-related changes in the expression of renal aldosterone-sensitive sodium transporters in Wistar-Kyoto rats: A comparison with SHR
In the present study we hypothesized that age-associated changes in the renal aldosterone/mineralocorticoid receptor (MR) system may differ between normotensive Wistar-Kyoto (WKY) and spontaneouslyExpand

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