Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs.

@article{Daz2000RoleOA,
  title={Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs.},
  author={Gonzalo J D{\'i}az and E. James Squires},
  journal={Journal of agricultural and food chemistry},
  year={2000},
  volume={48 3},
  pages={
          833-7
        }
}
The metabolism of 3-hydroxy-3-methylindolenine (HMI), a recently discovered metabolite of 3-methylindole (3MI, skatole) produced by porcine liver microsomes, was investigated in vitro using porcine liver cytosol. HMI was rapidly metabolized to a single product, 3-hydroxy-3-methyloxindole (HMOI), by porcine cytosol. By the use of the selective inhibitors menadione and quinacrine, it was shown that the enzyme responsible for the oxidation of HMI into HMOI was aldehyde oxidase (AO; aldehyde:oxygen… CONTINUE READING
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