Role of advanced glycation end products in cellular signaling☆

@inproceedings{Ott2014RoleOA,
  title={Role of advanced glycation end products in cellular signaling☆},
  author={Christiane Ott and Kathleen Jacobs and Elisa Haucke and Anne Navarrete Santos and Tilman Grune and Andreas Simm},
  booktitle={Redox biology},
  year={2014}
}
Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and… CONTINUE READING

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