Role of adrenoceptors and dopamine receptors in modulating left ventricular diastolic function.

  title={Role of adrenoceptors and dopamine receptors in modulating left ventricular diastolic function.},
  author={R M Lang and John D. Carroll and S. Nakamura and Haruki Itoh and Sol I. Rajfer},
  journal={Circulation research},
  volume={63 1},
Although both dopamine and dobutamine are potent positive inotropic agents, multiple studies indicate that dopamine may produce a rise in left ventricular (LV) filling pressure, while dobutamine often has the opposite effect. To ascertain the pharmacological and hemodynamic mechanisms responsible for the elevation in LV filling pressure observed with dopamine, we administered incremental infusions (2, 4, and 6 micrograms/kg/min) of dopamine to 18 open-chest, anesthetized dogs in the presence… 

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