Role of adrenoceptors and dopamine receptors in modulating left ventricular diastolic function.

@article{Lang1988RoleOA,
  title={Role of adrenoceptors and dopamine receptors in modulating left ventricular diastolic function.},
  author={R M Lang and John D. Carroll and S. Nakamura and Haruki Itoh and Sol I. Rajfer},
  journal={Circulation research},
  year={1988},
  volume={63 1},
  pages={
          126-34
        }
}
Although both dopamine and dobutamine are potent positive inotropic agents, multiple studies indicate that dopamine may produce a rise in left ventricular (LV) filling pressure, while dobutamine often has the opposite effect. To ascertain the pharmacological and hemodynamic mechanisms responsible for the elevation in LV filling pressure observed with dopamine, we administered incremental infusions (2, 4, and 6 micrograms/kg/min) of dopamine to 18 open-chest, anesthetized dogs in the presence… 

Figures and Tables from this paper

Are the cardiovascular actions of dopamine altered by isoflurane?

TLDR
Dopamine seems theoretically to be a rationale choice when adrenergic support is needed to counter undesired cardiovascular depressant effects of isoflurane, but there are no reports on their pharmacological interaction.

Role of dopamine receptors and the utility of dopamine agonists in heart failure.

TLDR
Although the results of early clinical studies with some of these first-generation dopamine congeners are encouraging, analysis of ongoing large-scale placebo-controlled trials will provide valuable insight into their utility as therapeutic agents for patients with heart failure.

Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function

TLDR
It is concluded that in coronary artery disease patients with preserved systolic function dobutamine improves both relaxation and the early filling phase; these results add further information to the pharmacological effects of this drug.

Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs.

TLDR
The data indicate that toxic doses of TM may have a negative inotropic effect in conscious dogs and that treatment with propranolol or dobutamine HCl reversed some, but not all, of the effects caused by TM administration.

Diastolic heart failure

  • M. ZileJ. Nappi
  • Medicine, Biology
    Current treatment options in cardiovascular medicine
  • 2000
TLDR
The diagnosis of diastolic heart failure can be made when a patient has both symptoms and signs on physical exam of congestive heart failure, and normal left ventricular volume and ejection fraction.

Diastolic failure: pathophysiology and therapeutic implications.

New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function.

TLDR
A perspective on the criteria used to diagnose diastolic heart failure, the effects of diastolics heart failure on prognosis, and measurements used to assess diastsolic function are focused on.

Diastolic heart failure

A 78-year-old woman with a history of hypertension is admitted to the hospital with congestive heart failure. Physical examination reveals a blood pressure of 180/90 mm Hg, increased jugular venous

References

SHOWING 1-10 OF 45 REFERENCES

Role of Prejunctional α2‐Adrenergic Receptors in the Regulation of Myocardial Performance during Exercise in Conscious Dogs

TLDR
Observations indicate that, in the intact conscious animal, prejunctional α2-adrenoreceptors are stimulated during exercise, thereby modulating the norepinephrine release through a negative feedback inhibitory mechanism.

The differential effects of positive inotropic and vasodilator therapy on diastolic properties in patients with congestive cardiomyopathy.

TLDR
Positive inotropic therapy with beta 1-adrenoceptor agonists enhances early diastolic distensibility by accelerating relaxation, augmenting filling, and reducing end-systolic chamber size.

Comparative Systemic and Regional Hemodynamic Effects of Dopamine and Dobutamine in Patients with Cardiomyopathic Heart Failure

TLDR
The dose-response data demonstrated that dobutamine progressively and predictably increases cardiac output by increasing stroke volume, while simultaneously decreasing systemic and pulmonary vascular resistance and pulmonary capillary wedge pressure.

Myocardial relaxation. VI. Effects of beta-adrenergic tone and asynchrony on LV relaxation rate.

TLDR
The studies confirm the dependency of LV relaxation rate on systolic loads and indicate that this form of load-dependent relaxation can be modified by alterations in beta-adrenergic tone and LV asynchrony, suggesting the importance of temporal dispersion of the contraction-relaxation sequence as a mechanism responsible for disturbed relaxation.

Dobutamine: DEVELOPMENT OF A NEW CATECHOLAMINE TO SELECTIVELY INCREASE CARDIAC CONTRACTILITY

TLDR
Experiments on dogs showed that the resulting drug, dobutamine, had an inotropic efficacy as great as that of epinephrine due to a direct action on β1 cardiac receptors, however, do butamine's effect on α and β2 vascular receptors was slight.

Drugs five years later. Dobutamine.

TLDR
Dobutamine should be used to improve ventricular function and cardiac performance in patients in whom ventricular dysfunction has caused a reduced stroke volume and cardiac output, a mild to moderate drop in systemic blood pressure, diminished organ and tissue perfusion and elevated ventricular filling pressures.

Modulation of noradrenaline release by peripheral presynaptic alpha 2-adrenoceptors in humans.

TLDR
The present investigation supports the concept of a presynaptic alpha 2-adrenoceptor modulating noradrenaline release from sympathetic nerve endings via a negative feedback mechanism in humans.

Comparison of the cardiovascular actions of dopamine and epinine in the dog.

TLDR
Experiments in animals treated with hexamethonium to block ganglion transmission and propranolol to block beta adrenoceptors revealed that both selective alpha-1 (terazosin) and alpha-2 (rauwolscine) adrenoceptor antagonists inhibited the vasopressor response to DA to a greater degree than the responses to epinine.

The Cardiovascular Effects of the Continuous Infusion of Dobutamine in Patients with Severe Cardiac Failure

TLDR
The improvement of cardiac function without the simultaneous development or exacerbation of undesirable effects (tachycardia, premature ventricular contractions, increased pulmonary or systemic resistance, tachyphylaxis, etc.) makes dobutamine a highly desirable inotropic agent.

Comparison of dobutamine and dopamine in treatment of severe heart failure.

TLDR
It is concluded that dobutamine is an effective, positive inotropic agent in patients with severe congestive heart failure and may be of special value in Patients with the low output syndrome associated with coronary heart disease.