Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment.

@article{Bryant1991RoleOA,
  title={Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment.},
  author={Henry U. Bryant and E W Bernton and Julie R. Kenner and John W. Holaday},
  journal={Endocrinology},
  year={1991},
  volume={128 6},
  pages={3253-8}
}
Implantation of a 75-mg morphine pellet in sham-adrenalectomized male C3H/HeN mice resulted in significant elevations of serum corticosterone levels within 6 h. Corticosterone levels remained elevated (3- to 4-fold) for 72 h and had returned to normal by 120 h postimplantation. Within 48 h of pellet implantation, morphine-pelleted mice exhibited marked reductions in spleen (35%) and thymus weight (56%) relative to values in placebo-pelleted controls. In addition, adrenal hypertrophy was… CONTINUE READING