Role of adrenal and gonadal androgens in insulin action and metabolism.

@article{Kitabchi1991RoleOA,
  title={Role of adrenal and gonadal androgens in insulin action and metabolism.},
  author={Abbas E. Kitabchi and Cynthia K. Buffington and J R Givens and Hiroyuki Inouye},
  journal={Nihon Naibunpi Gakkai zasshi},
  year={1991},
  volume={67 3},
  pages={203-13}
}
In a previous report we found extreme hyperinsulinemia associated with high testosterone levels in patients with polycystic ovarian syndrome (PCO) and normal insulin levels in a small group of patients with elevated dehydroepiandrosterone (DHEA). From these observations, we hypothesized that DHEA and testosterone may have opposing actions on insulin sensitivity. To test this hypothesis, we studied insulin sensitivity in vivo and in vitro in a) obese PCO women with elevated testosterone, b… CONTINUE READING