Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets.

  title={Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets.},
  author={Sajid Umar Khan and Samriddhi Shukla and Sonam Sinha and Syed Musthapa Meeran},
  journal={Cytokine & growth factor reviews},
  volume={24 6},
Obesity is the cause of a large proportion of breast cancer incidences and mortality in post-menopausal women. In obese people, elevated levels of various growth factors such as insulin and insulin-like growth factors (IGFs) are found. Elevated insulin level leads to increased secretion of estrogen by binding to the circulating sex hormone binding globulin (SHBG). The increased estrogen-mediated downstream signaling favors breast carcinogenesis. Obesity leads to altered expression profiles of… CONTINUE READING
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