Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets.

@article{Khan2013RoleOA,
  title={Role of adipokines and cytokines in obesity-associated breast cancer: therapeutic targets.},
  author={Sajid Umar Khan and Samriddhi Shukla and Sonam Sinha and Syed Musthapa Meeran},
  journal={Cytokine & growth factor reviews},
  year={2013},
  volume={24 6},
  pages={503-13}
}
Obesity is the cause of a large proportion of breast cancer incidences and mortality in post-menopausal women. In obese people, elevated levels of various growth factors such as insulin and insulin-like growth factors (IGFs) are found. Elevated insulin level leads to increased secretion of estrogen by binding to the circulating sex hormone binding globulin (SHBG). The increased estrogen-mediated downstream signaling favors breast carcinogenesis. Obesity leads to altered expression profiles of… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 143 references

Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells.

International journal of cancer • 2009
View 4 Excerpts
Highly Influenced

Adiponectin and adiponectin receptors.

Endocrine reviews • 2005
View 5 Excerpts
Highly Influenced

Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.

Current drug targets. Immune, endocrine and metabolic disorders • 2003
View 4 Excerpts
Highly Influenced

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