Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo.

@article{Karpatkin1988RoleOA,
  title={Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo.},
  author={Simon Karpatkin and Edward Pearlstein and C Ambrogio and Barry S. Coller},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={81 4},
  pages={
          1012-9
        }
}
Platelet-adhesive protein-tumor cell interaction was studied in vitro and in vivo. Monoclonal antibody 10E5, which inhibits binding of fibronectin and von Willebrand factor to the platelet membrane glycoprotein GPIIb-GPIIIa complex, inhibited the binding of mouse CT26 and human HCT8 colon carcinoma cells to platelets by 63-65%, whereas an irrelevant monoclonal antibody, 3B2, had no effect. Monoclonal antibody 6D1, which inhibits binding of von Willebrand factor to GPIb, also had no effect. RGDS… CONTINUE READING

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