Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells.

@article{Schnurr2004RoleOA,
  title={Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells.},
  author={Max Schnurr and Tracey Toy and Amanda Shin and Gunther Hartmann and Simon Rothenfusser and Julia Soellner and Ian D Davis and Jonathan S. Cebon and Eugene Maraskovsky},
  journal={Blood},
  year={2004},
  volume={103 4},
  pages={1391-7}
}
Plasmacytoid dendritic cells (PDCs) are potent regulators of immune function and the major source of type I interferon (IFN) following viral infection. PDCs are found at sites of inflammation in allergic reactions, autoimmune disorders, and cancer, but the mechanisms leading to the recruitment of PDCs to these sites remain elusive. During inflammation, adenosine is released and functions as a signaling molecule via adenosine receptors. This study analyzes adenosine receptor expression and… CONTINUE READING