Role of adenosine in the sympathetic activation produced by isometric exercise in humans.

@article{Costa1994RoleOA,
  title={Role of adenosine in the sympathetic activation produced by isometric exercise in humans.},
  author={Fernando Costa and Italo Biaggioni},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 4},
  pages={1654-60}
}
Isometric exercise increases sympathetic nerve activity and blood pressure. This exercise pressor reflex is partly mediated by metabolic products activating muscle afferents (metaboreceptors). Whereas adenosine is a known inhibitory neuromodulator, there is increasing evidence that it activates afferent nerves. We, therefore, examined the hypothesis that adenosine stimulates muscle afferents and participates in the exercise pressor reflex in healthy volunteers. Intraarterial administration of… CONTINUE READING
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