• Corpus ID: 22693941

Role of adenosine in sleep in rats.

  title={Role of adenosine in sleep in rats.},
  author={Miodrag Radulova{\vc}ki},
  journal={Reviews in clinical \& basic pharmacology},
  volume={5 3-4},
  • M. Radulovački
  • Published 1 July 1985
  • Biology, Chemistry, Psychology
  • Reviews in clinical & basic pharmacology
The effects on sleep of N6-L-(phenylisopropyl) adenosine, cyclohexyladenosine and adenosine-5'-ethylcarboxamide were studied in rats. Also, the effects on sleep of deoxycoformycin, a potent inhibitor of adenosine deaminase, and adenosine were examined. In addition, we determined the effects of 48 h of REM sleep deprivation on adenosine (A1) receptors in specific brain structures. N6-L-(phenylisopropyl) adenosine and cyclohexyl-adenosine increased deep slow wave sleep and REM sleep whereas… 

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