• DOI:10.1016/0091-3057(91)90317-U
Corpus ID: 31833466

Role of adenosine in sleep and temperature regulation in the preoptic area of rats

@article{Ticho1991RoleOA,
  title={Role of adenosine in sleep and temperature regulation in the preoptic area of rats},
  author={S. Ticho and M. Radulova{\vc}ki},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={40},
  pages={33-40}
}

• S. Ticho, M. Radulovački
• Published 1991
• Chemistry, Medicine
• Pharmacology Biochemistry and Behavior

We have examined the effects on sleep and brain temperature of bilateral microinjections of adenosine and adenosine analogs to the preoptic area (PO) of rats. Administration of adenosine (12.5 nmoles), a nonselective adenosine A1/A2 receptor agonist NECA (N-ethyl-carboxamido-adenosine, 1.0 nmole), and the selective adenosine A1 receptor agonist CPA (cyclopentyladenosine, 0.25, 0.5 nmoles) increased total sleep primarily through an enhancement in deep slow-wave sleep (SWS2), while adenosine also… Expand

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