Role of adenosine in sleep and temperature regulation in the preoptic area of rats

@article{Ticho1991RoleOA,
  title={Role of adenosine in sleep and temperature regulation in the preoptic area of rats},
  author={S. Ticho and M. Radulova{\vc}ki},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={40},
  pages={33-40}
}
We have examined the effects on sleep and brain temperature of bilateral microinjections of adenosine and adenosine analogs to the preoptic area (PO) of rats. Administration of adenosine (12.5 nmoles), a nonselective adenosine A1/A2 receptor agonist NECA (N-ethyl-carboxamido-adenosine, 1.0 nmole), and the selective adenosine A1 receptor agonist CPA (cyclopentyladenosine, 0.25, 0.5 nmoles) increased total sleep primarily through an enhancement in deep slow-wave sleep (SWS2), while adenosine also… Expand
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