Role of adenosine in platelet-mediated reduction in pulmonary vascular permeability.

@article{Paty1992RoleOA,
  title={Role of adenosine in platelet-mediated reduction in pulmonary vascular permeability.},
  author={Philip S.K. Paty and P M Sherman and Jon M. Shepard and Asrar B. Malik and John E Kaplan},
  journal={The American journal of physiology},
  year={1992},
  volume={262 3 Pt 2},
  pages={H771-7}
}
Previous studies have shown that platelets decrease 125I-labeled albumin permeability across confluent bovine pulmonary artery endothelial cell monolayers. In the current study, we addressed the role of platelets and platelet-derived adenosine (ADO) in vascular barrier function with cultured endothelial cells and isolated perfused lungs. Both 7 x 10(7) platelets/ml and conditioned media prepared from the same concentration of platelets reduced albumin permeability of endothelial monolayers by… CONTINUE READING