Role of adenosine in delayed preconditioning of myocardium.

  title={Role of adenosine in delayed preconditioning of myocardium.},
  author={Gary F. Baxter},
  journal={Cardiovascular research},
  volume={55 3},
Myocardial protection conferred by ischemic preconditioning occurs in a bimodal time course. The early cardioprotection wanes rapidly and is succeeded by a delayed phase of protection reducing infarct development, myocardial stunning and arrhythmias. This 'second window' of preconditioning may be evident for up to 72 h. The current mechanistic paradigm for delayed preconditioning against infarction invokes roles for several freely-diffusible molecules, generated during the preconditioning… CONTINUE READING
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