Role of activin-A and follistatin in foam cell formation of THP-1 macrophages.

@article{Kozaki1997RoleOA,
  title={Role of activin-A and follistatin in foam cell formation of THP-1 macrophages.},
  author={Koichi Kozaki and Masahiro Akishita and Masato Eto and Masanori Yoshizumi and Ken Toba and Shujiro Inoue and Masakazu Ishikawa and Masayoshi Hashimoto and Tatsuhiko Kodama and Nobuhiro Yamada and Hajime Orimo and Yasuyoshi Ouchi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 11},
  pages={2389-94}
}
Macrophage (M phi) foam cell formation is a characteristic event that occurs in the early stage of atherosclerosis. To examine the roles of activin-A, a member of the transforming growth factor-beta superfamily, and follistatin, the binding protein for activin-A, in M phi function, we investigated their effects on foam cell formation of THP-1 M phi s. When THP-1 M phi s were treated with activin-A (5 nmol/L), foam cell formation and cellular cholesteryl ester accumulation were decreased. This… CONTINUE READING

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