Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis.

@article{Manuel2007RoleOA,
  title={Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis.},
  author={Suba G. A. Manuel and Chandran Ragunath and Hameetha B. Rajamohamed Sait and Era A. Izano and Jeffrey B. Kaplan and N Ramasubbu},
  journal={The FEBS journal},
  year={2007},
  volume={274 22},
  pages={5987-99}
}
Dispersin B (DspB), a family 20 beta-hexosaminidase from the oral pathogen Aggregatibacter actinomycetemcomitans, cleaves beta(1,6)-linked N-acetylglucosamine polymer. In order to understand the substrate specificity of DspB, we have undertaken to characterize several conserved and nonconserved residues in the vicinity of the active site. The active sites of DspB and other family 20 hexosaminidases possess three highly conserved acidic residues, several aromatic residues and an arginine at… CONTINUE READING

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