Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors.

@article{Zieger2005RoleOA,
  title={Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors.},
  author={Karsten Zieger and Lars Dyrskj\ot and Carsten Wiuf and Jens L. Jensen and Claus Lindbjerg Andersen and Klaus M\oller-Ernst Jensen and Torben F. \Orntoft},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 21},
  pages={7709-19}
}
PURPOSE Bladder tumors develop through different molecular pathways. Recent reports suggest activating mutations of the fibroblast growth factor receptor 3 (FGFR3) gene as marker for the "papillary" pathway with good prognosis, in contrast to the more malignant "carcinoma in situ" (CIS) pathway. The aim of this clinical follow-up study was to investigate the role of FGFR3 mutations in bladder cancer development in a longitudinal study. EXPERIMENTAL DESIGN We selected 85 patients with… CONTINUE READING

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