Role of action potential shortening in the prevention of arrhythmias in canine cardiac tissue.

Abstract

1. The effects of the K+ channel opener diazoxide and the oxime-containing Ca2+ and K+ channel blocker salicylaldoxime were tested in canine cardiac Purkinje tissue. 2. Both drugs shortened action potential duration (APD). For salicylaldoxime (0.1-1.0 mmol/L), the reductions in APD were statistically significant at the 25% level of repolarization (APD25… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.