Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress

Abstract

Clostridium botulinum C2 toxin (C2 toxin) and purified ADP-ribosylated-α-actin (ADP-r-α-actin) cause specific actin depolymerisation in living cells. This effect was used to investigate the actin microfilament system with particular emphasis on cell-cell adhesion and plasma membrane integrity in endothelial cells. C2 toxin caused time- and dose-dependent… (More)
DOI: 10.1007/s004240100589

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