Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide

Abstract

BACKGROUND In motile cells, protrusion of the lamellipodium (a type of cell margin) requires assembly of actin monomers into actin filaments at the tip of the lamellipodium. The importance of actin-filament disassembly in this process is less well understood, and is assessed here using the actin drug jasplakinolide, which has two known activities… (More)
DOI: 10.1016/S0960-9822(99)80478-3

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