Role of acid-sensing ion channel 3 in sub-acute-phase inflammation

  title={Role of acid-sensing ion channel 3 in sub-acute-phase inflammation},
  author={Yi-Tin Yen and Pang-Hsien Tu and C Chen and Yi-Wen Lin and S T Hsieh and Chih-Cheng Chen},
  journal={Molecular Pain},
  pages={1 - 1}
BACKGROUND Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nociceptors. Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators. However, the role of ASIC3 in inflammation remains inconclusive because of conflicting results generated from studies of ASIC3 knockout (ASIC3-/-) or dominant-negative mutant mice, which have shown normal, decreased or… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 41 extracted citations

Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?

American journal of physiology. Renal physiology • 2009
View 17 Excerpts
Highly Influenced

Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2018
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 39 references

Acid-sensing ion channels in sensory perception.

The Journal of biological chemistry • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…