Role of acid-sensing ion channel 3 in sub-acute-phase inflammation

@article{Yen2009RoleOA,
  title={Role of acid-sensing ion channel 3 in sub-acute-phase inflammation},
  author={Yi-Tin Yen and Pang-Hsien Tu and C Chen and Yi-Wen Lin and S T Hsieh and Chih-Cheng Chen},
  journal={Molecular Pain},
  year={2009},
  volume={5},
  pages={1 - 1}
}
BACKGROUND Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nociceptors. Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators. However, the role of ASIC3 in inflammation remains inconclusive because of conflicting results generated from studies of ASIC3 knockout (ASIC3-/-) or dominant-negative mutant mice, which have shown normal, decreased or… CONTINUE READING

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