Role of acid-base physiology on the pathogenesis of parturient hypocalcaemia (milk fever)--the DCAD theory in principal and practice.

@article{Goff2003RoleOA,
  title={Role of acid-base physiology on the pathogenesis of parturient hypocalcaemia (milk fever)--the DCAD theory in principal and practice.},
  author={Jesse P. Goff and Ronald L. van der Horst},
  journal={Acta veterinaria Scandinavica. Supplementum},
  year={2003},
  volume={97},
  pages={51-6}
}
The hypocalcemia associated with the clinical disease known as milk fever is due to a failure of the calcium homeostatic mechanisms in the cow to restore normal blood calcium concentration in a timely manner at the onset of lactation. The defect in calcium homeostasis appears to reside in the sensitivity of bone and kidney tissues to parathyroid hormone (PTH) stimulation. Evidence suggests the acid-base status of the cow dictates the sensitivity of the tissues to PTH stimulation, and that… CONTINUE READING

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