Role of acid and duodenogastric reflux in esophageal mucosal injury: a review of animal and human studies.

@article{Vaezi1995RoleOA,
  title={Role of acid and duodenogastric reflux in esophageal mucosal injury: a review of animal and human studies.},
  author={Michael Fredrick Vaezi and Shivendra Singh and J E Richter},
  journal={Gastroenterology},
  year={1995},
  volume={108 6},
  pages={1897-907}
}
The role of acid and duodenogastric reflux (DGR) in the development of esophageal mucosal injury has been extensively investigated using both animal and human models. In this report, clinical and experimental data are reviewed. The mechanisms by which gastric and duodenal contents produce esophageal mucosal injury are also discussed. Acid and pepsin are unquestionably important in causing mucosal damage at low pH values in both animal and human models. Animal models suggest synergistic damaging… CONTINUE READING

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