Role of acetaldehyde in tobacco smoke addiction

  title={Role of acetaldehyde in tobacco smoke addiction},
  author={R. Talhout and A. Opperhuizen and J. V. Amsterdam},
  journal={European Neuropsychopharmacology},
  • R. Talhout, A. Opperhuizen, J. V. Amsterdam
  • Published 2007
  • Chemistry, Medicine
  • European Neuropsychopharmacology
  • This review evaluates the presumed contribution of acetaldehyde to tobacco smoke addiction. In rodents, acetaldehyde induces reinforcing effects, and acts in concert with nicotine. Harman and salsolinol, condensation products of acetaldehyde and biogenic amines, may be responsible for the observed reinforcing effect of acetaldehyde. Harman and salsolinol inhibit monoamine oxidase (MAO), and some MAO-inhibitors are known to increase nicotine self-administration and maintain behavioural… CONTINUE READING
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