Role of acetaldehyde in tobacco smoke addiction

  title={Role of acetaldehyde in tobacco smoke addiction},
  author={Reinskje Talhout and Antoon Opperhuizen and J. G. C. Amsterdam},
  journal={European Neuropsychopharmacology},

Contribution of Monoamine Oxidase Inhibition to Tobacco Dependence: A Review of the Evidence.

  • R. Hogg
  • Medicine, Biology
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2016
A comprehensive review of the available evidence for the role of MAO inhibition by tobacco-derived substances in tobacco dependence points the way for further research in this field.

Harmane Potentiates Nicotine Reinforcement Through MAO-A Inhibition at the Dose Related to Cigarette Smoking

It is found that harmane potentiated nicotine self-administration on the fixed ration schedule at the dose related to human cigarette smoking by the synergistic effects in up-regulating genes in addiction-related pathways, and the effect was reduced at doses 10 times higher or lower than the smoking-related dose.

The Role of Harmane and Norharmane in In Vitro Dopaminergic Function

Along with downregulation of protein expression, notably MAO-B, the data indicate the potential of harmane and norharmane to act in synergy with nicotine in midbrain neurons.

Elimination of Cigarette Smoke-derived Acetaldehyde in Saliva by Slow-release L-Cysteine Lozenge Is a Potential New Method to Assist Smoking Cessation. A Randomised, Double-blind, Placebo-controlled Intervention.

If the efficacy of Acetium lozenge can be confirmed in an adequately powered study, this new approach would represent a major breakthrough in smoking quit intervention because slow-release L-cysteine is non-toxic with no side-effects or limitations of use.

Repeated Administration of Cigarette Smoke Condensate Increases Glutamate Levels and Behavioral Sensitization

It is suggested that the CSC-induced psychomotor activities are closely associated with the elevation of glutamate concentrations in the rat dorsal striatum, which would suggest that the reinforcing effects of tobacco dependence are related to the hyperactivation of glutamate levels.

Tobacco smoke exposure induces nicotine dependence in rats

Tobacco smoke exposure leads to nicotine dependence as indicated by precipitated affective and somatic withdrawal signs and induces an upregulation of nAChRs in the hippocampus.

Salsolinol-like compounds as biomarkers of human alcohol consumption, disease and toxicity

A combined method for detection of catecholamines and tetrahydroisoquinolines by LC-MS/MS is developed, which achieves linearity to four orders of magnitude and is used clinically for diagnosing rare tumors called pheochromocytomas and paragangliomas.

Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization via Hyperstimulation of Glutamate Response in the Dorsal Striatum

It is suggested that non-nicotine alkaloids in commercial cigarette smoke synergistically act with nicotine on nAChRs, thereby upregulating glutamatergic response in the dorsal striatum, which contributes to the hypersensitization of psychomotor behaviors.

Biologically Active Compounds Present in Tobacco Smoke: Potential Interactions Between Smoking and Mental Health

This mini-review summarises what is currently known about the components of tobacco smoke with potential to have positive effects on smokers and investigates the subjective reports of a positive effect of smoking due to nicotine, of some other components, or are they a manifestation of the relief from nicotine withdrawal symptoms that smoking provides.



Monoamine oxidases and tobacco smoking.

It is speculated that MAO inhibition by compounds found in either tobacco or tobacco smoke can potentiate nicotine's effects and more effective anti-smoking drug strategies may be developed.

Acetaldehyde and its condensation products as markers in alcoholism.

  • M. Collins
  • Medicine
    Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
  • 1988
Although several condensation products have initial appeal as clinical or pathological indicators in chronic alcoholism, thorough and statistically sound studies are needed before conclusions can be reached concerning any particular biogenic amine-derived product.

Nicotine and nonnicotine factors in cigarette addiction

  • J. Rose
  • Psychology, Medicine
  • 2005
While current NRT methods have been the mainstay of smoking cessation treatment and will likely continue to serve a useful role, the next stage of progress will likely entail the development of tools designed with recognition of the importance of nonnicotine components of cigarette smoking.

Platelet monoamine oxidase, smoking cessation, and tobacco withdrawal symptoms.

The view that MAO inhibition from non-nicotine constituents in cigarette smoke is relevant to tobacco dependence is supported and that continued investigation of the potential use of MAO inhibitors in smoking cessation treatment is warranted.

Monoamine Oxidase Inhibition Dramatically Increases the Motivation to Self-Administer Nicotine in Rats

The results suggest that the inhibition of MAO activity by compounds present in tobacco smoke may combine with nicotine to produce the intense reinforcing properties of cigarette smoking that lead to addiction.

Acetaldehyde in mainstream tobacco smoke: formation and occurrence in smoke and bioavailability in the smoker.

Experimental data supports the following conclusions: Tobacco sugar-derived MS smoke acetaldehyde from commercial cigarettes is unlikely to result in direct central nervous system effects on the smoker.

Neuropharmacological actions of cigarette smoke: brain monoamine oxidase B (MAO B) inhibition.

Though nicotine is at the core of the neuropharmacological actions of tobacco smoke, MAO B inhibition may also be an important variable in understanding and treating tobacco smoke addiction.