Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease.

Abstract

Nitric oxide (NO) is an important signaling molecule that is generated through the catalytic activity of nitric oxide synthase (NOS). In the brain, NO mediates neuronal survival, synaptic plasticity, vascular smooth muscle relaxation, and endothelial cell permeability. Previous studies demonstrated aberrant expression of the NOS-III gene in neurons and… (More)

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@article{Monte2000RoleOA, title={Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease.}, author={Suzanne de la Monte and Y. K. Sohn and Daniel Etienne and Jeannette Kraft and Jack R Wands}, journal={Annals of the New York Academy of Sciences}, year={2000}, volume={903}, pages={61-71} }