Role of a short open reading frame in ribosome shunt on the cauliflower mosaic virus RNA leader.

@article{Pooggin2000RoleOA,
  title={Role of a short open reading frame in ribosome shunt on the cauliflower mosaic virus RNA leader.},
  author={Mikhail M Pooggin and Thomas Peter Erich Hohn and Johannes F{\"u}tterer},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 23},
  pages={17288-96}
}
The pregenomic 35 S RNA of cauliflower mosaic virus (CaMV) belongs to the growing number of mRNAs known to have a complex leader sequence. The 612-nucleotide leader contains several short open reading frames (sORFs) and forms an extended hairpin structure. Downstream translation of 35 S RNA is nevertheless possible due to the ribosome shunt mechanism, by which ribosomes are directly transferred from a take-off site near the capped 5' end of the leader to a landing site near its 3' end. There… CONTINUE READING

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