Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361)

@article{Todorov1999RoleOA,
  title={Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361)},
  author={Penio T. Todorov and William N Field and Michael John Dr. Tisdale},
  journal={British Journal of Cancer},
  year={1999},
  volume={80},
  pages={1734 - 1737}
}
SummaryHuman melanoma, G361, which induces cachexia in nude mice, has been shown to produce a proteolysis-inducing factor (PIF) of Mr 24 000, which is immunologically identical to that isolated from a cachexia-inducing murine tumour (MAC16). Biosynthetic labelling of G361 cells using a combination of [35S]sulphate and [6-3H]glucosamine gave a single component of Mr 24 000 after affinity chromatography employing a murine monoclonal antibody. The material contained both radiolabels and, after… CONTINUE READING
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