Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59.


CD59 antigen is a membrane glycoprotein that inhibits the activity of the C9 component of the C5b-9 membrane attack complex (MAC), thereby protecting human cells from lysis by human complement. The complement-inhibitory activity of CD59 is species-selective, and is most effective toward C9 derived from human or other primate plasma. The species-selective… (More)


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