Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.

@article{Studer1994RoleOA,
  title={Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.},
  author={Mich{\`e}le Studer and Heike P{\"o}pperl and Heather N Marshall and Atsushi Kuroiwa and Robb K Krumlauf},
  journal={Science},
  year={1994},
  volume={265 5179},
  pages={
          1728-32
        }
}
After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point… CONTINUE READING
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