Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.

  title={Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.},
  author={Mich{\`e}le Studer and Heike P{\"o}pperl and Heather N Marshall and Atsushi Kuroiwa and Robb K Krumlauf},
  volume={265 5179},
After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point… CONTINUE READING
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Publications referenced by this paper.

Trends Biochem . Sci . 17 , 427 ( 1992 ) ; H . Stunnenberg , Bioessays 15 , 309 ( 1993 ) ; S . A . Klieweret al

P. W. R. Rigby
Proc . Natl . Acad . Sci . U . S . A . • 1991