Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma.

  title={Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma.},
  author={Ralph Anthony Francescone and Steve J Scully and Michael Faibish and Sherry L. Taylor and Dennis H Oh and Luis Moral and Wei Yan and Brooke A Bentley and Rong Shao},
  journal={The Journal of biological chemistry},
  volume={286 17},
Glioblastoma is one of the most fatal cancers, characterized by a strong vascularized phenotype. YKL-40, a secreted glycoprotein, is overexpressed in patients with glioblastomas and has potential as a novel tumor biomarker. The molecular mechanisms of YKL-40 in glioblastoma development, however, are poorly understood. Here, we aimed to elucidate the role YKL-40 plays in the regulation of VEGF expression, tumor angiogenesis, and radioresistance. YKL-40 up-regulated VEGF expression in… CONTINUE READING


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