Role of YAP/TAZ in mechanotransduction

@article{Dupont2011RoleOY,
  title={Role of YAP/TAZ in mechanotransduction},
  author={Sirio Dupont and Leonardo Morsut and Maria Aragona and Elena Enzo and Stefano Giulitti and Michelangelo Cordenonsi and Francesca Zanconato and Jimmy le Digabel and Mattia Forcato and Silvio Bicciato and Nicola Elvassore and Stefano Piccolo},
  journal={Nature},
  year={2011},
  volume={474},
  pages={179-183}
}
Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth, differentiation and cancer malignant progression, but how rigidity mechanosensing is ultimately linked to activity of nuclear transcription factors remains… Expand
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  • S. Dupont
  • Biology, Medicine
  • Experimental cell research
  • 2016
TLDR
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TLDR
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TLDR
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FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis
TLDR
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