Role of YAP/TAZ in mechanotransduction

@article{Dupont2011RoleOY,
  title={Role of YAP/TAZ in mechanotransduction},
  author={Sirio Dupont and Leonardo Morsut and Maria Aragona and Elena Enzo and Stefano Giulitti and Michelangelo Cordenonsi and Francesca Zanconato and Jimmy le Digabel and Mattia Forcato and Silvio Bicciato and Nicola Elvassore and Stefano Piccolo},
  journal={Nature},
  year={2011},
  volume={474},
  pages={179-183}
}
Cells perceive their microenvironment not only through soluble signals but also through physical and mechanical cues, such as extracellular matrix (ECM) stiffness or confined adhesiveness. By mechanotransduction systems, cells translate these stimuli into biochemical signals controlling multiple aspects of cell behaviour, including growth, differentiation and cancer malignant progression, but how rigidity mechanosensing is ultimately linked to activity of nuclear transcription factors remains… Expand
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TLDR
This study shows that physical and mechanical cues regulate cell behaviour through the activation of YAP and TAZ, and that, in addition to Hippo signalling, these transcription factors can be activated through a pathway that relies on RHO activity and cytoskeletal tension. Expand
Control of cellular responses to mechanical cues through YAP/TAZ regulation
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This review will focus on how mechanical perturbations are sensed through changes in the actin cytoskeleton and mechanosensors at focal adhesions, adherens junctions, and the nuclear envelope to regulate YAP/TAZ. Expand
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction.
  • S. Dupont
  • Biology, Medicine
  • Experimental cell research
  • 2016
TLDR
Recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues are discussed. Expand
Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells.
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It is reported that actomyosin-generated cytoskeletal tension regulates nuclear shape and force transmission through the cytoskeleton and demonstrated the differential short- and long-term response of mesenchymal stem cells to dynamic tensile loading based on the contractility state, the patency of the actin cytos skeleton, and the connections it makes with the nucleus. Expand
Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression
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The biomechanical cues in the tissue microenvironment are summarized and an update on the roles of YAP/TAZ in mechanotransduction in various physiological and pathological conditions is provided. Expand
Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway.
TLDR
It is proposed that Agrin acts as a mechanotransduction signal in the ECM and promotes oncogenesis through YAP-dependent transcription and is clinically relevant in human liver cancer. Expand
Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells
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Angiomotin (AMOT), which can bind both F-actin and the neurosuppressive transcriptional coactivator Yes-associated protein (YAP), is critical for mechanotransduction in NSCs and is identified as an important intermediate signal transducer that allows N SCs to sense and respond to extracellular stiffness cues. Expand
Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading.
TLDR
YAP repression is sufficient to prompt MSC adipogenesis, regardless of a permissive biological environment, TEAD nuclear presence or focal adhesion stabilization, and is proposed a practical example of the exploitation of adipogenic transdifferentiation in tumors by harnessing the potential of YAP mechanical regulation. Expand
The Nuclear Lamina: From Mechanosensing in Differentiation to Cancer Cell Migration
TLDR
Signaling pathways that regulate lamin levels and decisions of cell fate in response to matrix mechanics combined with molecular cues are summarized. Expand
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis
TLDR
It is shown that FAK controls the nuclear translocation and activation of YAP in response to mechanical activation and submitted that the YAP‐dependent process of durotaxis requires a cell with an asymmetric distribution of active and inactive FAK molecules. Expand
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References

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TLDR
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TLDR
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TLDR
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TLDR
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