Role of WUSCHEL in Regulating Stem Cell Fate in the Arabidopsis Shoot Meristem

@article{Mayer1998RoleOW,
  title={Role of WUSCHEL in Regulating Stem Cell Fate in the Arabidopsis Shoot Meristem},
  author={Klaus F. X. Mayer and Heiko Schoof and Achim Haecker and Michael Lenhard and Gerd J{\"u}rgens and Thomas Laux},
  journal={Cell},
  year={1998},
  volume={95},
  pages={805-815}
}

Figures from this paper

WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex.
TLDR
It is shown that maintenance of the WUS gradient is essential to regulate stem cell number and Migration of a stem cell-inducing transcription factor into adjacent cells to activate a negative regulator, thereby restricting its own accumulation, is a theme that is unique to plant stem cell niches.
WUSCHEL induces shoot stem cell activity and developmental plasticity in the root meristem.
TLDR
WUS establishes stem cells with intrinsic shoot identity and responsive to developmental inputs that normally do not change root identity in root induced shoot stem cell identity and leaf development, floral development, or embryogenesis.
Shoot stem cell specification in roots by the WUSCHEL transcription factor
TLDR
The present research shows that activation of WUS function in the root inhibits the responses to exogenous auxin and suppresses the initiation and growth of lateral roots, and provides evidence for the manner by which WUS specifies stem-cell identity: by affecting auxin responses, by reducing the cell mitotic activity and by repressing other developmental pathways.
Combined SHOOT MERISTEMLESS and WUSCHEL trigger ectopic organogenesis in Arabidopsis.
TLDR
It is suggested that WUS produces a non-cell autonomous signal that activates cell division in combination with STM and that combined WUS/STM functions can initiate the progression from stem cells to organ initiation.
SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem.
TLDR
It is shown that the putative transcription factor SCR, first identified by its role in radial patterning, is required cell-autonomously for distal specification of the QC, which in turn regulates stem cell fate of immediately surrounding cells.
Shoot and floral meristem maintenance in arabidopsis.
TLDR
Recent results demonstrating that the fate of stem cells in Arabidopsis shoot and floral meristems is controlled by overlapping spatial and temporal signaling systems are summarized.
The WUSCHEL and SHOOTMERISTEMLESS genes fulfil complementary roles in Arabidopsis shoot meristem regulation.
TLDR
The results suggest that WUS and STM share labour in the shoot apical meristem: WUS specifies a subset of cells in the centre as stem cells, while STM is required to suppress differentiation throughout the meristsem dome, thus allowing stem cell daughters to be amplified before they are incorporated into organs.
Stem cell regulation in the shoot meristem
TLDR
Genetic and molecular analyses have shown that a feedback signaling loop between stem cells and the organizing center balances stem cell renewal versus differentiation, which allows the plant to maintain the organization of the shoot meristem despite a changing cellular context.
...
...

References

SHOWING 1-10 OF 120 REFERENCES
Role of the ZWILLE gene in the regulation of central shoot meristem cell fate during Arabidopsis embryogenesis
TLDR
It is proposed that ZLL relays positional information required to maintain stem cells of the developing shoot meristem in an undifferentiated state during the transition from embryonic development to repetitive postembryonic organ formation.
Cell fate regulation in the shoot meristem.
TLDR
Genetic data suggest a simple model in which graded positional information is provided by antagonistic gene functions and is interpreted by genes which regulate cell fate, which suggests the destiny of each cell depends on its position within the dynamic shoot meristem.
Short-range control of cell differentiation in the Arabidopsis root meristem
TLDR
The data indicate that pattern formation in the root meristem is controlled by a balance between short-range signals inhibiting differentiation and signals that reinforce cell fate decisions, which are strikingly similar to examples in animal development, such as during delamination of Drosophila neuroblasts.
Homeobox genes in the functioning of plant meristems.
TLDR
The maize homebox gene knotted1 (kn1) is expressed in vegetative and floral meristems and is down-regulated at the site of primordia formation, providing molecular markers for meristem initiation.
The WUSCHEL gene is required for shoot and floral meristem integrity in Arabidopsis.
TLDR
The results suggest that the WUS gene is specifically required for central meristem identity of shoot and floral meristems to maintain their structural and functional integrity.
...
...