Role of WNT signaling in epididymal sperm maturation

  title={Role of WNT signaling in epididymal sperm maturation},
  author={Jin Cheng and Ji-Xin Tang and Jian Li and Yu-Qian Wang and Xiuxia Wang and Yan Zhang and Su-Ren Chen and Yi-Xun Liu},
  journal={Journal of Assisted Reproduction and Genetics},
PurposeSpermatozoa maturation, a process required for spermatozoa to acquire progressive motility and the ability to fertilize ova, primarily occurs in the caput and corpus of the epididymis. Despite considerable efforts, the factor(s) promoting epididymal sperm maturation remains unclear. Recently, WNT signaling has been implicated in epididymal sperm maturation.MethodsTo further investigate WNT signaling function in epididymal sperm maturation, we generated Wntless conditional knockout mice… 
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