Role of Vitamin D3 in Modulation of ΔNp63α Expression during UVB Induced Tumor Formation in SKH-1 Mice

@inproceedings{Hill2014RoleOV,
  title={Role of Vitamin D3 in Modulation of ΔNp63α Expression during UVB Induced Tumor Formation in SKH-1 Mice},
  author={Natasha T. Hill and Gabriel H. Gracia-Maldonado and Mary Kathryn Leonard and Amanda R. Harper and Kathleen L. Tober and Tatiana M. Oberyszyn and Madhavi P. Kadakia},
  booktitle={PloS one},
  year={2014}
}
ΔNp63α, a proto-oncogene, is up-regulated in non-melanoma skin cancers and directly regulates the expression of both Vitamin D receptor (VDR) and phosphatase and tensin homologue deleted on chromosome ten (PTEN). Since ΔNp63α has been shown to inhibit cell invasion via regulation of VDR, we wanted to determine whether dietary Vitamin D3 protected against UVB induced tumor formation in SKH-1 mice, a model for squamous cell carcinoma development. We examined whether there was a correlation… CONTINUE READING