Role of Vegetation-Associated Protease Activity in Valve Destruction in Human Infective Endocarditis

Abstract

AIMS Infective endocarditis (IE) is characterized by septic thrombi (vegetations) attached on heart valves, consisting of microbial colonization of the valvular endocardium, that may eventually lead to congestive heart failure or stroke subsequent to systemic embolism. We hypothesized that host defense activation may be directly involved in tissue… (More)
DOI: 10.1371/journal.pone.0045695

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