Role of Twist in vasculogenic mimicry formation in hypoxic hepatocellular carcinoma cells in vitro.

@article{Ma2011RoleOT,
  title={Role of Twist in vasculogenic mimicry formation in hypoxic hepatocellular carcinoma cells in vitro.},
  author={Jin-lu Ma and Su-xia Han and Qiang Zhu and Jing Zhao and Dongxue Zhang and L Wang and Yi Lv},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={408 4},
  pages={
          686-91
        }
}
Vasculogenic mimicry (VM) refers to the unique ability of highly aggressive human tumor cells to form matrix-rich networks de novo when cultured on a three-dimensional matrix, thus mimicking embryonic vasculogenesis. Some studies have shown that tumor hypoxia can promote tumor cells to form vessel-like tubes in vitro and express genes associated with VM. Although, the mechanisms involved in hypoxia-induced VM remain elusive, we hypothesized that the epithelial-mesenchymal transition (EMT… CONTINUE READING
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