Role of Tropomodulin’s Leucine Rich Repeat Domain in the Formation of Neurite-like Processes

Abstract

Actin dynamics is fundamental for neurite development; monomer depolymerization from pointed ends is rate-limiting in actin treadmilling. Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1-Tmod3 are expressed in brain cells. We investigated the role of Tmod's C-terminal (LRR) domain in the… (More)
DOI: 10.1021/bi401431k

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