Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer

  title={Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer},
  author={Parul Singh},
  journal={IOSR Journal of Pharmacy},
  • Parul Singh
  • Published 2012
  • Medicine
  • IOSR Journal of Pharmacy
Ascorbic acid, a water soluble vitamin, helps in collagen assembly, synthesis of neurotransmitters, has immune functions and also acts as a major antioxidant in the body. Refractory corneal ulcer is a challenging situation faced by every ophthalmologist in developing countries. Available treatment options for refractory corneal ulcer are bandage contact lens, grid keratotomy, therapeutic penetrating keratoplasty, amniotic membrane transplantation, nerve growth factors, aprotinin [proteases… Expand
5 Citations


Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns.
  • 48
  • PDF
Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns.
  • 85
  • PDF
The efficacy of ascorbate treatment after severe experimental alkali burns depends upon the route of administration.
  • 31
  • PDF
Wound healing in rat cornea: the role of electric currents
  • 156
The organization of collagen in the corneal stroma.
  • 227
Additional clinical and morphological observations on the favorable effect of ascorbate in experimental ocular alkali burns.
  • 47
The intraocular fluids.
  • W. Foulds
  • Medicine
  • Transactions of the ophthalmological societies of the United Kingdom
  • 1977
  • 18
The intraocular fluids.
  • 31
The intraocular fluids. In The Eye, Davson H, editor
  • New York,
  • 1969