Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer

  title={Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer},
  author={Parul Singh},
  journal={IOSR Journal of Pharmacy},
  • Parul Singh
  • Published 2012
  • Medicine
  • IOSR Journal of Pharmacy
Ascorbic acid, a water soluble vitamin, helps in collagen assembly, synthesis of neurotransmitters, has immune functions and also acts as a major antioxidant in the body. Refractory corneal ulcer is a challenging situation faced by every ophthalmologist in developing countries. Available treatment options for refractory corneal ulcer are bandage contact lens, grid keratotomy, therapeutic penetrating keratoplasty, amniotic membrane transplantation, nerve growth factors, aprotinin [proteases… 

Wound Healing with Vitamin C

There was a significant difference on improving the burn between two groups, and Vitamin C takes a significant effect on improved the burn.

Insight into the Wound Healing Properties of Vitamin C

Water-soluble Vitamin C is inevitable and important for the synthesis of collagen and also aids as a surrounding material for body tissues, blood vessels, cartilages, bone, teeth, skin. In addition,

The efficacy of topical human amniotic membrane-mesenchymal stem cell-conditioned medium (hAMMSC-CM) and a mixture of topical hAMMSC-CM + vitamin C and hAMMSC-CM + vitamin E on chronic plantar ulcers in leprosy:a randomized control trial

Comparing the effects of topical human amniotic membrane-mesenchymal stem cell-conditioned medium alone and with vitamins C and E on healing of CPUL found hAMMSC-CM + vitamin E is best for healing ofCPUL.

The effects of topical vitamin C solution on the necrotic tissue volume of burn wounds

According to the results of this study, topical administration of vitamin C could be largely effective in the treatment of second-degree burn wounds.

The Efficacy of Human Amniotic Membrane Mesenchymal Stem Cells (hAMMSC) Plus Vitamin C for Treating Chronic Plantar Ulcer in Leprosy Patient: A Case Report

Amniotic membrane stem cell (AMSC) conditioned medium provide growth factors and sitokin for the chronic ulcer’s healing and Vitamin C as antioxidant, anti inflamatory, dan collagen synthesis can be useful for wound healing.

The Effects of Topical Vitamin C on Burn Wound Healing

The repeated-measures ANOVA data indicated that the study groups were significantly different concerning the final mean scores given to the wounds; thus, topical application of vitamin C significantly improved wound healing in the study participants.

Pengaruh Pemberian Topikal Campuran Produk Metabolit Amniotic Membrane Stem Cell (AMSC) pada Penyembuhan Ulkus Plantar Kronis Morbus Hansen

Pemberian topikal campuran produk metabolit AMSC dengan vitamin C pada prosentase penyembuhan ulkus plantar kronis Morbus Hansen yang lebih cepat dibandingkan perawatan standar dengan framycetin gauze dressing (FGD).

The effect of topical vitamin C solution on granulation tissue formation in burn wounds

This document is intended to help clarify the role of language in the training of interpreters and interpreters for visually impaired people.

Evaluation of the effects of Vitamin C on Epithelialization of Burn Wounds: A Randomized Clinical Trial

Results of repeated measures ANOVA showed a statistically significant difference in mean scores of the wound between the two treatments, wound healing significantly differed in the two groups and topical vitamin C solution had a significant effect on the acceleration of wound Epithelialization.



Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns.

Prior studies demonstrating that subcutaneous administration of ascorbate decreases corneal ulcerations after alkali burns are confirmed, as well as preliminary studies established the ocular acceptability, penetrability, and stability of the solutions used.

Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns.

It is suggested that exogenous maintenance of adequate aqueous humor levels of ascorbic acid overcomes the relatively scorbutic state of the anterior segment induced by a 12 mm. alkali burn, thereby impairing the development of corneal ulceration and perforation.

Effect of topical ascorbic acid on free radical tissue damage and inflammatory cell influx in the cornea after excimer laser corneal surgery.

Topical ascorbic acid application decreased oxygen radical tissue damage following excimer keratectomy and was shown to reduce the acute inflammatory reaction efficiently, suggesting that topical ascorBic acid could be considered a complementary treatment in the pharmacological modulation after excimer laser corneal surgery.

The efficacy of ascorbate treatment after severe experimental alkali burns depends upon the route of administration.

Immediate topical treatment of identically burned rabbit eyes achieved greatly elevated aqueous humor ascorbate levels and provided substantial protection from corneal ulceration and perforation.

Wound healing in rat cornea: the role of electric currents

Using vibrating probe techniques, detailed temporal and spatial mapping of endogenous electric currents at rat corneal wounds are provided and it is found Cl− and Na+ are the major components of electric currents in rat corNEal wounds.

The organization of collagen in the corneal stroma.

The intraocular fluids.

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  • Medicine
    Transactions of the ophthalmological societies of the United Kingdom
  • 1977

Additional clinical and morphological observations on the favorable effect of ascorbate in experimental ocular alkali burns.

The intraocular fluids. In The Eye, Davson H, editor

  • New York,
  • 1969