Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer

@article{Singh2012RoleOT,
  title={Role of Topical Ascorbic Acid in Management of Refractory Corneal Ulcer},
  author={Parul Singh},
  journal={IOSR Journal of Pharmacy},
  year={2012},
  volume={2},
  pages={01-04}
}
  • Parul Singh
  • Published 2012
  • Medicine
  • IOSR Journal of Pharmacy
Ascorbic acid, a water soluble vitamin, helps in collagen assembly, synthesis of neurotransmitters, has immune functions and also acts as a major antioxidant in the body. Refractory corneal ulcer is a challenging situation faced by every ophthalmologist in developing countries. Available treatment options for refractory corneal ulcer are bandage contact lens, grid keratotomy, therapeutic penetrating keratoplasty, amniotic membrane transplantation, nerve growth factors, aprotinin [proteases… 

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Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns.

Prior studies demonstrating that subcutaneous administration of ascorbate decreases corneal ulcerations after alkali burns are confirmed, as well as preliminary studies established the ocular acceptability, penetrability, and stability of the solutions used.

Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns.

It is suggested that exogenous maintenance of adequate aqueous humor levels of ascorbic acid overcomes the relatively scorbutic state of the anterior segment induced by a 12 mm. alkali burn, thereby impairing the development of corneal ulceration and perforation.

Effect of topical ascorbic acid on free radical tissue damage and inflammatory cell influx in the cornea after excimer laser corneal surgery.

Topical ascorbic acid application decreased oxygen radical tissue damage following excimer keratectomy and was shown to reduce the acute inflammatory reaction efficiently, suggesting that topical ascorBic acid could be considered a complementary treatment in the pharmacological modulation after excimer laser corneal surgery.

The efficacy of ascorbate treatment after severe experimental alkali burns depends upon the route of administration.

Immediate topical treatment of identically burned rabbit eyes achieved greatly elevated aqueous humor ascorbate levels and provided substantial protection from corneal ulceration and perforation.

Wound healing in rat cornea: the role of electric currents

Using vibrating probe techniques, detailed temporal and spatial mapping of endogenous electric currents at rat corneal wounds are provided and it is found Cl− and Na+ are the major components of electric currents in rat corNEal wounds.

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Additional clinical and morphological observations on the favorable effect of ascorbate in experimental ocular alkali burns.

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