Role of Toll-like receptor 4 for the pathogenesis of acute lung injury in Gram-negative sepsis.

@article{Baumgarten2006RoleOT,
  title={Role of Toll-like receptor 4 for the pathogenesis of acute lung injury in Gram-negative sepsis.},
  author={Georg Baumgarten and Pascal Knuefermann and Herrmann Wrigge and Ch. Putensen and Heidi Stapel and Klaus Fink and Ralf Meyer and Andreas Hoeft and Christian M. Grohe},
  journal={European journal of anaesthesiology},
  year={2006},
  volume={23 12},
  pages={1041-8}
}
BACKGROUND AND OBJECTIVE Proinflammatory cytokines as well as nitric oxide (NO) play a major role in mediating the response to lipopolysaccharide (LPS). The present study tested the hypothesis that LPS induces proinflammatory cytokines in the lung via the Toll-like receptor 4 (TLR4)/CD14 signalling cascade. METHODS Control mice and TLR4-deficient (TLR4-D) mice were used to test TLR4-mediated effects of LPS. Both strains received either Escherichia coli LPS (20 mg kg-1 intraperitoneal) or… CONTINUE READING