Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.

  title={Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.},
  author={Abdolmohamad M. Rostami and Bogoljub Ciric},
  journal={Journal of the neurological sciences},
  volume={333 1-2},
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). The etiology of MS is not well understood, but it is believed that myelin-specific CD4(+) T cells play a central role in initiating and orchestrating CNS inflammation. In this scenario, CD4(+) T cells, activated in the periphery, infiltrate the CNS, where, by secreting cytokines and chemokines, they start an inflammatory cascade. Given the central role of CD4(+) T cells in CNS autoimmunity, they have been… CONTINUE READING
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