Role of Tat Protein in HIV Neuropathogenesis

  title={Role of Tat Protein in HIV Neuropathogenesis},
  author={Wenxue Li and Guanhan Li and Joseph P. Steiner and Avindra Nath},
  journal={Neurotoxicity Research},
The Tat protein of the human immunodeficiency virus (HIV) has been implicated in the pathophysiology of the neurocognitive deficits associated with HIV infection. This is the earliest protein to be produced by the proviral DNA in the infected cell. The protein not only drives the regulatory regions of the virus but may also be actively released from the cell and then interact with the cell surface receptors of other uninfected cells in the brain leading to cellular dysfunction. It may also be… CONTINUE READING