Role of TRPV-1 in CGRP-mediated trigeminal sensitization


Materials and methods CGRP (600 ng/kg) was intravenously injected to the Wistar rats (250-300 g). Rat trigeminal ganglia and brainstem were removed 45 and 60 minutes after CGRP or saline injection. The levels of CGRP, TRPV-1, phosphorylated PKC (p-PKC) and cyclic AMP responsive element-binding protein (CREB) in TG were determined by western blotting and by… (More)
DOI: 10.1186/1129-2377-14-S1-P72