Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.

  title={Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.},
  author={Bhargavi Kulkarni and Dileep Kumar and Nat{\'a}lia Cruz-Martins and Satheeshkumar Sellamuthu},
  journal={Molecular neurobiology},
Alzheimer's disease (AD) is a neurodegenerative disease characterized by an increasing deterioration of memory, which is concomitant with additional cognitive deficits. Neurofibrillary tangles and senile plaques are two pivotal proteins inside the brain that are considered essential to obstruct the normal cognitive function of the brain. Genetic variations in TREM2 gene disturb the neuroinflammatory action of microglia in reducing the progression of the disease.TREM2 is a transmembrane receptor… 

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