Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury.

@article{Gao2008RoleOT,
  title={Role of TNF-alpha-induced reactive oxygen species in endothelial dysfunction during reperfusion injury.},
  author={Xue Feng Gao and Hanrui Zhang and Souad Belmadani and Junxi Wu and Xiangbin Xu and Howard L. Elford and Barry J Potter and Cuihua Zhang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 6},
  pages={H2242-9}
}
We hypothesized that neutralization of TNF-alpha at the time of reperfusion exerts a salubrious role on endothelial function and reduces the production of reactive oxygen species. We employed a mouse model of myocardial ischemia-reperfusion (I/R, 30 min/90 min) and administered TNF-alpha neutralizing antibodies at the time of reperfusion. I/R elevated TNF-alpha expression (mRNA and protein), whereas administration of anti-TNF-alpha before reperfusion attenuated TNF-alpha expression. We detected… CONTINUE READING