Role of TNF-alpha in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia.

@article{Shahani2000RoleOT,
  title={Role of TNF-alpha in myocardial dysfunction after hemorrhagic shock and lower-torso ischemia.},
  author={Rohan Shahani and J Gordon Marshall and Barry B. Rubin and R. K.-Y. Li and Paul Michael Walker and Thomas F. Lindsay},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={278 3},
  pages={H942-50}
}
Ruptured abdominal aortic aneurysm (RAAA) repair, a combination of hemorrhagic shock and lower-torso ischemia, is associated with a 50-70% mortality. Myocardial dysfunction may contribute to the high rate of mortality after aneurysm repair. We attempted to determine whether RAAA repair results in cardiac dysfunction mediated by tumor necrosis factor-alpha (TNF-alpha). We modeled aortic rupture and repair in the rat by inducing hemorrhagic shock to a mean blood pressure of 50 mmHg for 1 h… CONTINUE READING
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