Role of TNF-α but not NGF in murine hyperalgesia induced by parasitic infection

  title={Role of TNF-α but not NGF in murine hyperalgesia induced by parasitic infection},
  author={Luigi Aloe and Rolando Moroni and Francesco Angelucci and Marco Fiore},
Using adult mice infected with the trematode Schistosoma mansoni, we observed that this infection induces both thermal hyperalgesia and an increase in the levels of nerve growth factor in the paws. To explore the mechanism involved in peripheral hypersensitivity during chronic infection, mice were infected with 60 cercariae of S. mansoni and injected 17 weeks later with nerve growth factor, anti-nerve growth factor or with other molecules known to be associated with hyperalgesic processes. The… CONTINUE READING
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