Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

@article{Btous2009RoleOT,
  title={Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.},
  author={R{\'e}my B{\'e}tous and Laurie Rey and Guliang Wang and Marie-Jeanne Pillaire and Nadine Puget and Janick S{\`e}lves and Denis Biard and Kazuo Shin-Ya and Karen M. Vasquez and Christophe Cazaux and J S Hoffmann},
  journal={Molecular carcinogenesis},
  year={2009},
  volume={48 4},
  pages={
          369-78
        }
}
Accurate DNA replication during S-phase is fundamental to maintain genome integrity. During this critical process, replication forks frequently encounter obstacles that impede their progression. While the regulatory pathways which act in response to exogenous replication stress are beginning to emerge, the mechanisms by which fork integrity is maintained at naturally occurring endogenous replication-impeding sequences remains obscure. Notably, little is known about how cells replicate through… CONTINUE READING
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