Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge.

@article{Cole2011RoleOT,
  title={Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challenge.},
  author={Leah E. Cole and Barbara J. Mann and Kari Ann Shirey and Katharina Richard and Yang Yang and Patricia J Gearhart and Kirsty L Chesko and Rose Marie Viscardi and Stefanie N. Vogel},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 4},
  pages={
          787-97
        }
}
Immunization with Ft-LPS provokes an antigen-specific, B-1a cell-derived antibody response that protects WT mice against an otherwise lethal challenge with Ft LVS. However, this same regimen offers limited protection to TLR2(-/-) mice, despite production of WT levels of anti-Ft-LPS antibodies. As Ft-LPS exhibits no TLR2 agonist activity, and macrophage-induced cytokine production in response to Ft LVS is overwhelmingly TLR2-dependent, we hypothesized that treatment of TLR2(-/-) mice with an… CONTINUE READING
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Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge.

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