Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.

  title={Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.},
  author={Tomohiro Aoki and Hiroharu Kataoka and Takuya Moriwaki and Kazuhiko Nozaki and N. Hashimoto},
  volume={38 8},
BACKGROUND AND PURPOSE The degradation of extracellular matrix (ECM) is a hallmark of a cerebral aneurysm; however, little is known regarding the molecular mechanism leading to this change. Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs). We investigated the role of TIMPs in the progression of cerebral aneurysms in the present study. METHODS TIMP-1 and TIMP-2 expression was… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 44 extracted citations

The role of estrogen on the pathology of cerebral aneurysms.

Expert review of neurotherapeutics • 2016
View 11 Excerpts
Highly Influenced

Inflammation and Cerebral Aneurysms

Translational Stroke Research • 2013
View 5 Excerpts
Highly Influenced

Biology of intracranial aneurysms: role of inflammation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2012
View 9 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 25 references

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

PE Van den Steen, B Dubois, +3 authors G. Opdenakker
Crit Rev Biochem Mol Biol • 2002

Similar Papers

Loading similar papers…