Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.

@article{Aoki2007RoleOT,
  title={Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms.},
  author={Tomohiro Aoki and Hiroharu Kataoka and Takuya Moriwaki and Kazuhiko Nozaki and N. Hashimoto},
  journal={Stroke},
  year={2007},
  volume={38 8},
  pages={2337-45}
}
BACKGROUND AND PURPOSE The degradation of extracellular matrix (ECM) is a hallmark of a cerebral aneurysm; however, little is known regarding the molecular mechanism leading to this change. Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs). We investigated the role of TIMPs in the progression of cerebral aneurysms in the present study. METHODS TIMP-1 and TIMP-2 expression was… CONTINUE READING

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